MicroRNA 21 in tissue injury and inflammation: AUTHORS' RETROSPECTIVE
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چکیده
منابع مشابه
MicroRNA-21 in glomerular injury.
TGF-β(1) is a pleotropic growth factor that mediates glomerulosclerosis and podocyte apoptosis, hallmarks of glomerular diseases. The expression of microRNA-21 (miR-21) is regulated by TGF-β(1), and miR-21 inhibits apoptosis in cancer cells. TGF-β(1)-transgenic mice exhibit accelerated podocyte loss and glomerulosclerosis. We determined that miR-21 expression increases rapidly in cultured murin...
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BACKGROUND MicroRNA-21 (miR-21) is overexpressed in most inflammatory diseases, but its physiological role in gut inflammation and tissue injury is poorly understood. The goal of this work is to understand the role of miR-21 in colitis and damage progression of intestine in a genetically modified murine model. METHODS Experimental colitis was induced in miR-21 KO and wild-type (WT) mice by 3....
متن کاملTissue injury and inflammation
Inflammation is a very complicated phenomenon and consist a part of the immune response which is divided to a natural phase followed by an adaptive one. Tissue injury is followed by a cascade of events leading to the inflammatory response which is divided in three phases. The first phase of inflammation is manifested by the activation of the local tissue macrophagues which exert their phagocyti...
متن کاملOxygen radicals, inflammation, and tissue injury.
Inflammatory reactions often result in the activation and recruitment of phagocytic cells (e.g., neutrophils and/or tissue macrophages) whose products result in injury to the tissue. In killing of endothelial cells by activated neutrophils as well as in lung injury produced by either activated neutrophils or activated macrophages there is evidence that H2O2 and iron play a role. HO. may be a ke...
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Astrogliosis following spinal cord injury (SCI) involves an early hypertrophic response that serves to repair damaged blood-brain barrier and a subsequent hyperplastic response that results in a dense scar that impedes axon regeneration. The mechanisms regulating these two phases of astrogliosis are beginning to be elucidated. In this study, we found that microRNA-21 (miR-21) increases in a tim...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2012
ISSN: 0008-6363
DOI: 10.1093/cvr/cvs222